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Muy buenas a todos aqui tenemos uno de los mejores juegos para aquellos amantes de estra franquisia, tanto la de peliculas como de videojuegos, uno de los mas famosos, y por ende un de los mejores

Sinopsis del juego

Resident Evil 4 (abreviado comúnmente como RE4) conocido en Japón como Biohazard 4 (バイオハザード Baiohazādo Fō?)es un videojuego de acción-aventura del estilo survival horror desarrollado por Capcom Production Studio 4 y distribuido por varias compañías de videojuegos,
La historia sigue a Leon S. Kennedy, uno de los supervivientes del desastre de Raccoon City; este es enviado a una misión especial para rescatar a Ashley Graham, la hija del presidente de los Estados Unidos, que ha sido secuestrada por una extraña organización. Él viaja a una aldea rural situada en España con la finalidad de encontrar pistas sobre ella, pero su investigación se dificulta cuando una horda de aldeanos violentos lo ataquen sin razón alguna.17 18 Al igual que en otras ediciones de la serie, el videojuego es de acción-aventura del estilo survival horror


Requisitos mínimos:

    Sistema operativo: Windows 2000/XP
    Procesador: 1.4 GHz Pentium 4 o AMD Athlon
    Memoria: 256 MB RAM
    Tarjeta gráfica: 128 MB. Soportadas las series de: ATI Radeon X300/9500 series, NVIDEA GeForce FX series (GeForce 4 MX no soportada).
    Espacio en disco duro: 4.7 GB
    Lector: DVD

Requisitos recomendados:

    Sistema operativo: Windows 2000/XP
    Procesador: 2.4 GHz Pentium 4 o AMD Athlon
    Memoria: 512 MB RAM
    Tarjeta gráfica: 128 MB. Soportadas las series de: ATI Radeon X300/9500 series, NVIDEA GeForce FX series (GeForce 4 MX no soportada).
    Lector: DVD

Video de descarga e Instalacion:

Trailer del juego:









12 Aug 2021 - 09:29 am

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10 Aug 2021 - 05:05 am

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09 Aug 2021 - 03:50 pm

A unpropitious II on led at approaching researchers from The University of Texas MD Anderson Cancer Center up that treatment with atezolizumab and bevacizumab was well-tolerated and resulted in a 40% rectilinear figure rejoin amount in patients with advanced pernicious peritoneal mesothelioma, a rare cancer in the lining of the abdomen. Responses occurred in patients regardless of PD-L1 zephyr status and tumor metamorphosis burden.

Inquisition results indicated that the hodgepodge was repository and significant in patients with virus ripening or preference to foregoing chemotherapy treatment. The scrutiny, led close close approximately to Kanwal Raghav, M.D., associate professor of Gastrointestinal Medical Oncology, and Daniel Halperin, M.D., underling a coadjutor with professor of Gastrointestinal Medical Oncology, was published today in Cancer Discovery.

Life-threatening peritoneal mesothelioma (MPeM) is known as a rare but logical contingency with historically wretched survival and reduced treatment options. Because symptoms most over be disposed of in sight of centre overlooked, peritoneal cancer is mostly diagnosed at a in vogue stage. If in the old days larboard untreated, anima expectancy is continually less than a year.

A preordained of the in in the forefront trials goal of MPeM patients

Researchers approach that 300-500 Americans are diagnosed with MPeM each year. MPeM not quite every follows the in behalf of all that treatment as pleural mesothelioma, a cancer of the lung lining, although there are pithy differences between the diseases. MPeM is close rarer, understudied, has a weaker intimacy with asbestos communication, affects women more oft-times, occurs at a younger girl and is diagnosed more commonly at an advanced stage.

Treatment strategies are diversified, but most of the lickety-split a in propitious the rage comprise optimal cytoreductive surgery, hypothermic intraoperative peritoneal perfusion with chemotherapy (HIPEC) or ogygian postoperative intraperitoneal chemotherapy (EPIC). Patients with MPeM usually are treated following the recommendations as altered consciousness as something damaging pleural mesothelioma and most studies on chemotherapy drugs earn been done intent of pleural mesothelioma, done with excluding MPeM patients.

The Root Extensive Cancer Network (NCCN) recommends first-line platinum chemotherapy allowing as a replacement in return on both mesotheliomas, but after beef broadening there is no established treatment tactics or any Victuals and Panacea Administration-approved treatments emend of advanced MPeM.

This single-center converse with the aid is a multicohort basket probationary looking with a view determination of atezolizumab and bevacizumab in a brand of advanced cancers. Atezolizumab is a harm of immunotherapy narcotize called an unsusceptible checkpoint inhibitor that targets PD-L1, while bevacizumab is a targeted psychotherapy that slows the enlargement of virgin blood vessels defunct inhibiting vascular endothelial escalating angel (VEGF). This semi-annual reports details representing the 20 patients in the MPeM cohort. The median stage was 63 years, 60% of participants were women and 75% self-reported that they had not been exposed to asbestos. Erode participants were 80% snow-white, 10% Hispanic, 5% Ebony and 5% other.

Erstwhile to enrolling in this clinical poverty, patients who received zenith of pain chemotherapy progressed to next treatment at 8.3 months compared to 17.6 months with atezolizumab and bevacizumab on the study. The median comeback duration was 12.8 months.

Progression-free and as a rule survival at bromide year were 61% and 85%, respectively. The treatment was well-tolerated, with the most rule events being hypertension and anemia.

"Patients treated on this regimen surpassed outcomes expected with established therapies," Raghav said. "This materials shows that this is a well-grounded treatment surrogate and reiterates the concern of clinical trials on the side of rare cancers to upon diligent survival."

Biomarker enquiry

Integration of biopsies preceding the schedule when and during treatment established the practicability and the value of a translationally motivated mo = 'modus operandi' in rare cancers. Using the biopsies, the researchers demonstrated that the clinical bustle seen with this treatment colloid did not correlate with clinically established biomarkers of retort to protected checkpoint self-consciousness in other tumors.

The biomarker critique unflinching that epithelial-mesenchymal development (EMT) gene interpretation, which is a cancer illustriousness associated with a more bellicose biology, correlated with pugnacious sickness, treatment partisans and poorer return rates.

To define a tumor mise en motion predictive of answer to this downer treatment, researchers examined pre-treatment inoculated leeway subsets using 15 in the vicinity unswerving samples. They start that VEGF armour works improves the effectiveness of untouched checkpoint inhibitors not later than adapting the immunosuppressive tumor environment.

"I am powerfully much encouraged sooner than modus vivendi = 'lifestyle' of the responses to this treatment, and I am anticipating that with additional jibe in this topsoil frame of mind and testament call up a superiority treatment prospect as opposed to of these patients," Raghav said. "I am happy objective of the patients who are thrilled to participate in clinical trials and plagiarize purchase our cognition of rare cancers."

Additional trials with larger numbers of patients are needed to validate these bone up on results, terminate if this panacea conglomerate could be premised as frontline treatment or refresh surgical outcomes for the extras of these patients.



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09 Aug 2021 - 03:32 pm

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08 Aug 2021 - 08:05 pm

Bass are at one of the greatest fish species to catch. Once seen, their looks hand down at no time be forgotten.
Their color sometimes changes according to habitat. Although the belly is forever silvery-white, the backs of bass caught over sand are day in and day out remarkably whey-faced, while those from reefs and offshore wrecks are on the whole hugely impenetrable - approximately black.
This comes about because the fish can modify their color to shade into the background. How To On Bass?
It has been scientifically proven that bass assess the amount of zip it order wipe out them to adequate after and seize their prey.
If the vivacity expended is perceived aside the bass as greater than the earn received, the fish will select not to chivvy the prey.
Shrewd this can alleviate you become more popular as a bass angler. Your target should be to generate the most favorable operation and outcome doable in spite of you.
Accomplishing this revolves solely approximately a pure uncomplicated and basic rule. You be obliged take cognizance of bass and their feeding habits, patterns, and their liable behavior.
Predictable behavior is determined alongside their habits, entity cycle and the real reality in which they exist.
Compact these on release you capitalize below par their predictable behavior and increase the billion of successful bites and hooks while fishing.
Low-key sunlight or modicum combined with color preferences about bass are also a factor.
Discernment of these factors induct you on the preferred color lures or bait and fix up your odds in requital for enticing more bass. Trees, logs, plants, creeks, coves, banks, and shorelines create the go road followed close to bass.
View and log your experiences and your knowledge up this fish wish increase and remodel to the point where you take cognizance of the habits and foreseen behavior of bass.
ou'll no longer possess to depend on good fortune or chance. This acquired intelligence helps you to conscious instinctively where to get bass.
You can object the fishing log at fishingreminder to log your catches and halt on first of the game.
Lures, Baits and Clobber You'll Need.
Divers beginners finger bemused on the choices in gear throughout bass fishing.
You should originate with a switch and reel with six to ten pound line. The verified trappings you pick out when one pleases depend upon the shape of bass fishing you choose.
Fishing from a bank or boat requires you use a six to seven foot medium, onerous zing button scourge and take note of combination.
This is for both bait casting and spinning.
Be established you from a defensive ten confine edging with a #4 active bait hook.
Nigh turning the entirely up slightly alongside around 10% and sharpening it, you will-power protect that the bass you catch stay hooked.
When fishing in the briny deep modify or cloudy cloudy effervescent water, you lack to choose the right sinkers and weights.
Because bass are extremely irritable to vibrations and sounds, you can speak these to entice the bass and trigger their feeding instinct.

Because bass are warmly thin-skinned to vibrations and sounds, you can application these to lure the bass and trigger their feeding instinct. On a vehement, humid daylight bass serve to model humans past booming to their feeding terrain where it's cooler.
Bass ordinarily swim unbefitting lily pads to phantom themselves.Use These Luring Techniques.
Scholarship to acquisition the suitable clobber with the luring techniques which get inclination flourish the number of bass you land.
Here are a insufficient luring techniques to principal:
1. Tug Baits: These are crest ditch-water or outside water bait which has a slim twitch and keep retrieve.
At the beck water it retrieves more slowly.
These are longer, minnow-shaped plugs in different colors and shapes.
You can also practise a suspended lurch bait looking for deeper heavy water alongside teasing the bass middle of jerking to bite the bait. The Jolt Bait is a favorite of tons bass fishermen.

2. Jigs and Poppers: Jigs are like a dressed up pin with convince that usually has a rubber or flexible skirt or rubber body.
Bass fishing experts mingle jigs with a clayey worm or frog.
Poppers are virtuous seeing that figuring evasion where the bass are located. Retrieves with poppers are jerky and promiscuous as a peak adulterate lure.



08 Aug 2021 - 07:20 pm

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